Antiparallel coiled-coil-mediated dimerization of myosin X
نویسندگان
چکیده
منابع مشابه
X-ray crystal structure of a TRPM assembly domain reveals an antiparallel four-stranded coiled-coil.
Transient receptor potential (TRP) channels comprise a large family of tetrameric cation-selective ion channels that respond to diverse forms of sensory input. Earlier studies showed that members of the TRPM subclass possess a self-assembling tetrameric C-terminal cytoplasmic coiled-coil domain that underlies channel assembly and trafficking. Here, we present the high-resolution crystal structu...
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Myosin VI is a pointed-end-directed actin motor that is thought to function as both a transporter of cargoes and an anchor, capable of binding cellular components to actin for long periods. Dimerization via a predicted coiled coil was hypothesized to regulate activity and motor properties. However, the importance of the coiled-coil sequence has not been tested in vivo. We used myosin VI's well-...
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absorbed in the atmosphere, the NIR water vapor bands. Thus, we see no way of defending Stephen's statement that conclusions based on broad-band measurements (1) are inconsistent with other existing data sets where discrepancies were found to occur between measurements in spectral bands and theory. Instead, the broad-band solar absorption findings presented in our report (1) are entirely consis...
متن کاملInterhelical Salt Bridges , Coiled - Coil Stability , and Specificity of Dimerization
absorbed in the atmosphere, the NIR water vapor bands. Thus, we see no way of defending Stephen's statement that conclusions based on broad-band measurements (1) are inconsistent with other existing data sets where discrepancies were found to occur between measurements in spectral bands and theory. Instead, the broad-band solar absorption findings presented in our report (1) are entirely consis...
متن کاملProtein dissection of the antiparallel coiled coil from Escherichia coli seryl tRNA synthetase.
The alpha-helices of coiled-coil proteins are predominantly parallel, in contrast to the general preference for an antiparallel orientation of interacting alpha-helices found in globular proteins. One intriguing exception is the antiparallel, two-stranded coiled coil comprising the long helical arm of the bacterial seryl tRNA synthetases (SRS). A recombinant 82-residue peptide corresponding to ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1208642109